Pharmacoepidemiology

Inferring antenatal care visit timing in low- and middle-income countries: Methods to inform potential maternal vaccine coverage

The lack of data on the timing of antenatal care visits in low- and middle-income countries makes it difficult to model interventions delivered through this platform. Here, we use publicly available data to estimate the timing of antenatal care visits by gestational age in a variety of countries.

Medication persistence of targeted immunomodulators for plaque psoriasis: A retrospective analysis using a U.S. claims database

Measuring medication persistance of psoriasis drugs is difficult, because they have very different dosing intervals and most have an induction period with different dosing from the maintenance period. We show how the method of calculation contributes to the variation in persistence estimates that previous literature has shown.

Forecasting Demand for the Typhoid Conjugate Vaccine in Low- and Middle-income Countries

Background The World Health Organization (WHO) released a position paper in March 2018 calling for integration of a novel typhoid conjugate vaccine (TCV) into routine immunization along with catch-up campaigns for children up to age 15. Gavi, the …

Cost-Effectiveness of Targeted Pharmacotherapy for Moderate to Severe Plaque Psoriasis

Background Newer classes of targeted drugs for moderate to severe plaque psoriasis are more effective and more expensive than older classes, posing a difficult and potentially costly decision about whether to use them as initial targeted treatments. …

Forecasting demand for maternal influenza immunization in low- and lower-middle-income countries

Immunization of pregnant women against seasonal influenza remains limited in low- and lower-middle-income countries despite being recommended by the World Health Organization (WHO). The WHO/PATH Maternal Influenza Immunization Project was created to …

Integrating value of research into NCI Clinical Trials Cooperative Group research review and prioritization: A pilot study

Background The Institute of Medicine has called for approaches to help maximize the return on investments (ROI) in cancer clinical trials. Value of Research (VOR) is a health economics technique that estimates ROI and can inform research …

The economic impact of childhood acute gastroenteritis on Malawian families and the healthcare system

Objectives This prospective cohort study sought to estimate health system and household costs for episodes of diarrhoeal illness in Malawi. Setting Data were collected in two Malawian settings: a rural health centre in Chilumba and an urban tertiary …

Favorable and publicly funded studies are more likely to be published: a systematic review and meta-analysis

Objectives The aim of this study was to identify and quantify the characteristics of studies associated with the likelihood of publication. Study Design and Setting We searched for manuscripts that tracked cohorts of clinical studies (“cohorts”) that …

Characterizing Pharmacogenomic-Guided Medication Use With a Clinical Data Repository

Objectives This prospective cohort study sought to estimate health system and household costs for episodes of diarrhoeal illness in Malawi. Setting Data were collected in two Malawian settings: a rural health centre in Chilumba and an urban tertiary …